Treatment - Persistent edema of rosacea

Systemic

A combination therapy including isotretinoin 0,5 mg/kg body weight daily and ketotifen 1 – 2 mg daily is recommended.
Note: For female patients of childbearing age, the use of effective birth control is mandatory because of this drug’s teratogenic potential. Regular monitoring of cholesterine and triglyceride levels as well as liver enzymes is required during treatment. Simultaneous treatment with isotretinoin and oral tetracyclines is not indicated, as this could cause an increase in cranial pressure. Isotretinoin may worsen ophthalmic rosacea..