Isotretinoin 0,5 – 1 mg/kg body weight daily, for the first 2 weeks of therapy in combination with corticosteroids 0,5 – 1 mg/kg body weight daily is recommended. Note: For female patients of childbearing age, the use of effective birth control is mandatory because of this drug’s teratogenic potential. Regular monitoring of cholesterine and triglyceride levels as well as liver enzymes is required during treatment. Simultaneous treatment with isotretinoin and oral tetracyclines is not indicated, as this could cause an increase in cranial pressure. Isotretinoin may worsen ophthalmic rosacea..
Oral antibiotics may be used alternatively, such as tetracycline hydrochloride and minocycline.